The Effect of Strontium Ranelate on Fracture Healing: An Animal Study

Table 1

Comparison of histopathological results between groups receiving StR and controls at 2 and 4 weeks after study initiation.

	Control 2 w	Control 4 w	StR 2 w	StR 4 w
Callus diameter (mm)				^$##	<0.0001
Total callus area (mm^2)				^$	<0.0001
% cartilage					0.007
% fibrous tissue			^$$	^##	<0.0001
% osseous tissue			^$	^##	<0.0001
% new trabecular bone			73.00 ± 13.37	^#$	0.004
Total osteoclast number					0.502
Osteoclast number/mm^2				^#$	0.041
Osteoblast number/HPF			^$	^#	0.005
Total vessel number			^$		0.001
Vessels/mm^2				^$	0.012

We used the two-way ANOVA model without repeated measurements, with factors the “intervention” (control vs. drug) and “time” (2 weeks vs. 4 weeks). Multiple comparisons were performed using the Bonferroni test. Abbreviations: HPF: high-power field. vs. control 2 weeks and vs. control 2 w. ^$ vs. control 4 weeks and ^$$ vs. control 4 w. ^# vs. StR 2 weeks and ^## vs. StR 2 w.