LRG1 May Accelerate the Progression of ccRCC via the TGF-β Pathway

Figure 3

Promoter methylation level of LRG1 gene in ccRCC and subgroups. (a) Promoter methylation level of LRG1 gene is significantly downregulated compared with normal controls. (b) Methylation level of LRG1 gene in male and female patients is decreased compared with normal patients (). (c) Methylation level of LRG1 gene in different ages has significant differences compared with normal controls (). (d) Methylation level of LRG1 gene in different races has significant differences compared with normal controls (). (e) Methylation level of all of the stages are downregulated than normal controls (). (f) Methylation level of all of the grads are downregulated than normal controls (). (g) Methylation level of metastatic ccRCC is lower than nonmetastatic, but both of them are significantly downregulated than normal controls ().

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