BioMed Research International

Research Article

Comparative Transcriptome Analysis Reveals the Potential Cardiovascular Protective Targets of the Thyroid Hormone Metabolite 3-Iodothyronamine (3-T1AM)

Table 2

The 90 enriched genes associated with cardiovascular diseases analyzed with the Comparative Toxicogenomics Database.


Disease name	Disease categories	value	Corrected value	Annotated gene quantity	Annotated genes	Genome frequency

Cardiovascular diseases	Cardiovascular disease	2.81-13	3.78-10	90	ANXA1\|ATP7A\|BRAF\|CALM2\|CALU\|CAMK2D\|CANX\|CASP12\|CASQ2\|CCL2\|COX1\|COX2\|COX3\|CRBN\|CXCL1\|CYTB\|des\|DNM1L\|EIF2A\|ERAP1\|FKBP14\|FKTN\|GAA\|GATAD1\|GLRX3\|GSTA4\|GSTT1\|HIF1A\|HMGB1\|HMOX1\|HSF2\|HSPA9\|HSPD1\|JAK2\|KLF13\|KRAS\|MAOA\|MAPRE1\|MEX3C\|MFF\|NCL\|ND1\|ND5\|ND6\|NDUFS1\|NEDD4\|NEXN\|NF1\|NR3C1\|NR4A1\|NRAS\|NUCKS1\|NUP155\|PAK2\|PDIA3\|PON2\|PPP2CA\|PPP3R1\|PROS1\|PSEN2\|PSMA2\|PSMA6\|PSMB7\|PTP4A2\|RASA1\|RENBP\|ROCK2\|SCN1B\|SGCA\|SGCD\|SHOC2\|SIRT4\|SLC4A3\|STK39\|TAP1\|TBCA\|TFPI\|TFRC\|TLL1\|TNFAIP6\|TRIM63\|TRPM4\|UFD1\|UGCG\|USP34\|WDPCP\|WDR12\|WNK4\|XPO1\|YES1	1452/43293 genes: 3.35%

Heart diseases	Cardiovascular disease	7.42E-11	9.97E-08	68	BRAF\|CALM2\|CALU\|CAMK2D\|CANX\|CASP12\|CASQ2\|CCL2\|COX1\|des\|DNM1L\|EIF2A\|FKTN\|GAA\|GATAD1\|GLRX3\|HIF1A\|HMGB1\|HMOX1\|HSF2\|HSPA9\|HSPD1\|JAK2\|KLF13\|KRAS\|MAPRE1\|MEX3C\|MFF\|NCL\|NDUFS1\|NEDD4\|NEXN\|NF1\|NR3C1\|NR4A1\|NRAS\|NUCKS1\|NUP155\|PAK2\|PDIA3\|PPP2CA\|PPP3R1\|PSEN2\|PSMA2\|PSMA6\|PSMB7\|PTP4A2\|RENBP\|ROCK2\|SCN1B\|SGCA\|SGCD\|SHOC2\|SIRT4\|SLC4A3\|TAP1\|TBCA\|TFRC\|TLL1\|TRIM63\|TRPM4\|UFD1\|UGCG\|USP34\|WDPCP\|WDR12\|XPO1\|YES1	1066/43293 genes: 2.46%

MELAS syndrome	Cardiovascular disease \|Genetic disease (inborn) \|Metabolic disease \|Musculoskeletal disease \|Nervous system disease	1.20E-06	0.00161	7	COX1\|COX2\|COX3\|CYTB\|ND1\|ND5\|ND6	22/43293 genes: 0.05%

Vascular diseases	Cardiovascular disease	2.59E-06	0.00348	50	ANXA1\|ATP7A\|CAMK2D\|CANX\|CASP12\|CCL2\|COX1\|COX2\|COX3\|CRBN\|CXCL1\|CYTB\|DNM1L\|EIF2A\|ERAP1\|FKBP14\|GSTA4\|GSTT1\|HIF1A\|HMGB1\|HMOX1\|HSPA9\|HSPD1\|JAK2\|KLF13\|KRAS\|MAOA\|MAPRE1\|MFF\|NCL\|ND1\|ND5\|ND6\|NEDD4\|NR3C1\|NR4A1\|PDIA3\|PPP2CA\|PPP3R1\|PROS1\|PSMA6\|RASA1\|STK39\|TAP1\|TFPI\|TFRC\|TNFAIP6\|UGCG\|WDR12\|WNK4	917/43293 genes: 2.12%

Cardiomegaly	Cardiovascular disease \|Pathology (anatomical condition)	3.31E-06	0.00444	17	CASQ2\|des\|FKTN\|GAA\|GATAD1\|GLRX3\|HIF1A\|HMOX1\|NEXN\|PPP3R1\|PSEN2\|RENBP\|ROCK2\|SGCD\|SIRT4\|TRIM63\|WDR12	168/43293 genes: 0.39%

Cardiomyopathies	Cardiovascular disease	5.17E-06	0.00695	22	CASP12\|CASQ2\|CCL2\|COX1\|des\|FKTN\|GAA\|GATAD1\|HIF1A\|HMGB1\|HSPD1\|NDUFS1\|NEXN\|PSEN2\|RENBP\|SGCA\|SGCD\|SIRT4\|TBCA\|TFRC\|TRIM63\|WDR12	271/43293 genes: 0.63%

Cerebral small vessel diseases	Cardiovascular disease \|Nervous system disease	5.56E-06	0.00747	7	COX1\|COX2\|COX3\|CYTB\|ND1\|ND5\|ND6	27/43293 genes: 0.06%