Development and Evaluation of Oleanolic Acid Dosage Forms and Its Derivatives

Table 1

Pharmacokinetic data of different dosage forms of oleanolic acid.

Form	Dosage	Administration	AUC	C max	T max	T½	Bioavailability	Object	References
OA solution	0.5 mg/kg	Injection	16 mg min/ml			41.9 min	1	Male rat	[7]
	25 mg/kg	Oral gavages	5.9 mg min/ml	74 ng/ml	25 min	46.5 min	0.7%
Capsule	40 mg	Oral	124.29 ng h/ml	12.1 ng/ml	5.2 h	8.7 h		Adult male	[71]
Cyclodextrin inclusion	1 mL	Injection	4468.85 mg/L/min	103.97 mg/L	2 min	54.69 min	1	SD rat	[72]
		Oral gavages	89.42 mg/L/min	1.52 mg/L	45 min	42.53 min	2%
Solid dispersion	10 mg/kg	OA; Oral gavages; SD-OA	82.3 ng h/ml	24.95 ng/mL	1.25 h	4.99 h	183.07%	SD rat	[73]
			150.7 ng h/ml	99.58 ng/mL	0.49 h	2.23 h
Tablet	50 mg/kg	Oral gavages	25 mg h/ml	201.33 ng/mL	2.92 h	10.08 h		SD rat	[74]
SMEDDS	50 mg/kg	Oral gavages	1749.29 mg h/ml	70.09 ng/mL	2.02 h	4.17 h	402.24%	SD rat	[74]
Nanoparticles	10 mg/kg	Oral gavages	126.53 ng h/ml	12.6 ng/mL	0.33 h		340.5%	SD rat	[75]
Nanoliposome	50 mg/kg	Oral gavages	2471.7 ng h/ml	542.78 ng/mL	0.7 h	1.21 h	607.9%	SD rat	[76]
Phospholipid complex	50 mg/kg	Oral	360.6 ng h/ml	78.7 ng/mL	0.46 h		139.4%	SD rat	[77]