Review Article
Development and Evaluation of Oleanolic Acid Dosage Forms and Its Derivatives
Table 2
Structure-activity relationships for the main categories of derivatives.
| The position of the modification | Representative derivatives | Activities | References |
| A ring | | Antibacterial activity | [105] | Antiparasitic activity | [106] | Inhibitors against hCE1 | [107] | C-28 | | Inhibitory effect on serotonin | [108] | Promoting osteoblast activity | C ring | | Hepatoprotective effect | [109] | A ring and c-28 (amidation) | | Antitumor activity | [109] | Protective effect of cardiomyocytes | [110] | A ring and c-28 (esterification) | | Antimicrobial activity | [111] | Antitumor activity | [112] | A ring and c-28 (nitrogen-containing heterocycle) | | Antitumor activity | [113] |
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