Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer
Phloretin treatment induced morphological changes and decreased cell viability in prostate cancer cells. (a) After treating with different concentrations of phloretin (0, 20, 50, and 100 μM) in WPMY-1, LNCaP, CWR22Rv1, PC-3, and DU145 cells ( cells/well) for 24 h, cell morphological changes were observed and photographed with microscope (Nikon microscope, Japan) under 10x magnification. (b, c) WPMY-1, LNCaP, CWR22Rv1, PC-3, and DU145 cells were treated with different concentrations of phloretin (0, 20, 50, and 100 μM) for 24 h, and then cells were harvested for MTT and CCK-8 assays, respectively. The percentages of cell viabilities were calculated by comparing with control samples. ,.
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