Research Article
Associations between NLRC4 Gene Polymorphisms and Autoimmune Thyroid Disease
Table 2
Allele frequencies and genotype distribution of NLRC4 polymorphisms in AITD patients and controls.
| | Gene/SNP | Controls | AITD | value(OR, 95% CI) | GD | value(OR, 95% CI) | HT | value(OR, 95% CI) | | NLRC4 | (%) | (%) | AITD vs. control | (%) | GD vs. control | (%) | HT vs. control |
| | rs385076 | | | T | 926(59.28) | 1271(63.23) | 0.016(0.847,0.739-0.970) | 788(62.64) | 0.070(0.868,0.746-1.011) | 483(64.23) | 0.022(0.811,0.677-0.971) | | C | 636(40.72) | 739(36.77) | 470(37.36) | 269(35.77) | | TT | 266(34.06) | 394(39.20) | 0.048- | 238(37.84) | 0.169- | 156(41.49) | 0.046- | | TC | 394(50.45) | 483(48.06) | 312(49.60) | 171(45.48) | | CC | 121(15.49) | 128(12.74) | 79(12.56) | 49(13.03) | | rs455060 | | | A | 715(45.77) | 872(43.38) | 0.154(1.102,0.964-1.258) | 547(43.48) | 0.224(1.097,0.945-1.274) | 325(43.22) | 0.247(1.109,0.931-1.322) | | G | 847(54.23) | 1138(56.62) | 711(56.52) | 427(56.78) | | AA | 160(20.49) | 181(18.01) | 0.335- | 109(17.33) | 0.322- | 72(19.15) | 0.421- | | AG | 395(50.58) | 510(50.75) | 329(52.31) | 181(48.14) | | GG | 226(28.93) | 314(31.24) | 191(30.36) | 123(32.71) | | rs212704 | | | T | 718(45.97) | 871(43.33) | 0.116(1.112,0.974-1.271) | 546(43.40) | 0.173(1.109,0.955-1.288) | 325(43.22) | 0.213(1.118,0.938-1.332) | | C | 844(54.03) | 1139(56.67) | 712(56.60) | 427(56.78) | | TT | 164(21.00) | 180(17.91) | 0.23- | 111(17.65) | 0.28- | 69(18.35) | 0.455- | | TC | 390(49.93) | 511(50.85) | 324(51.51) | 187(49.73) | | CC | 227(29.07) | 314(31.24) | 194(30.84) | 120(31.92) | | rs675712 | | | A | 923(59.09) | 1184(58.91) | 0.911(1.008,0.881-1.153) | 737(58.59) | 0.786(1.021,0.878-1.187) | 447(59.44) | 0.872(0.986,0.826-1.177) | | G | 639(40.91) | 826(41.09) | 521(41.41) | 305(40.56) | | AA | 276(35.34) | 361(35.92) | 0.783- | 228(36.25) | 0.497- | 133(35.37) | 0.957- | | AG | 371(47.50) | 462(45.97) | 281(44.67) | 181(48.14) | | GG | 134(17.16) | 182(18.11) | 120(19.08) | 62(16.49) |
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AITD: autoimmune thyroid disease; GD: Graves’ disease; HT: Hashimoto’s thyroiditis.
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