Associations between NLRC4 Gene Polymorphisms and Autoimmune Thyroid Disease
Table 3
Odds ratios (ORs) of the associations of four polymorphisms in the NLRC4 gene with AITD before and after adjusting for confounders (age and gender).
Comparison models
Unadjusted estimates
Adjusted estimates
OR (95% CI)
values
OR (95% CI)
values
rs385076
Allele model
0.84 (0.73-0.97)
0.014
0.84 (0.73-0.97)
0.014
Dominant model
0.80 (0.66-0.97)
0.026
0.80 (0.66-0.97)
0.027
Recessive model
0.80 (0.61-1.04)
0.096
0.79 (0.60-1.04)
0.091
Homozygous model
0.85 (0.73-0.98)
0.024
0.84 (0.72-0.98)
0.023
rs455060
Allele model
0.91 (0.79-1.04)
0.148
0.91 (0.79-1.04)
0.169
Dominant model
0.90 (0.73-1.10)
0.293
0.91 (0.74-1.11)
0.348
Recessive model
0.85 (0.67-1.08)
0.187
0.85 (0.67-1.08)
0.183
Homozygous model
0.90 (0.79-1.03)
0.140
0.90 (0.79-1.04)
0.154
rs212704
Allele model
0.90 (0.78-1.03)
0.112
0.90 (0.79-1.04)
0.149
Dominant model
0.90 (0.74-1.11)
0.320
0.92 (0.74-1.13)
0.403
Recessive model
0.82 (0.65-1.04)
0.101
0.83 (0.65-1.05)
0.117
Homozygous model
0.89 (0.78-1.02)
0.095
0.90 (0.78-1.03)
0.122
rs675712
Allele model
1.01 (0.88-1.15)
0.913
1.02 (0.89-1.17)
0.760
Dominant model
0.97 (0.80-1.19)
0.799
1.00 (0.83-1.23)
0.965
Recessive model
1.07 (0.84-1.37)
0.601
1.07 (0.83-1.37)
0.610
Homozygous model
1.02 (0.89-1.17)
0.786
1.03 (0.90-1.18)
0.688
AITD: autoimmune thyroid disease; OR: odds ratio; 95% CI: 95% confidence interval; age and gender were adjusted in the multivariate logistic regression analyses.
