Associations between NLRC4 Gene Polymorphisms and Autoimmune Thyroid Disease
Table 5
Odds ratios (ORs) of the associations of four polymorphisms in the NLRC4 gene with HT before and after adjusting for confounders (age and gender).
Comparison models
Unadjusted estimates
Adjusted estimates
OR (95% CI)
values
OR (95% CI)
values
rs385076
Allele model
0.81 (0.67-0.97)
0.021
0.79 (0.65-0.95)
0.013
Dominant model
0.73 (0.57-0.94)
0.014
0.72 (0.55-0.94)
0.014
Recessive model
0.82 (0.57-1.17)
0.269
0.75 (0.52-1.09)
0.138
Homozygous model
0.83 (0.69-1.01)
0.060
0.80 (0.65-0.98)
0.028
rs455060
Allele model
0.90 (0.76-1.07)
0.246
0.88 (0.73-1.05)
0.164
Dominant model
0.84 (0.64-1.09)
0.190
0.83 (0.63-1.10)
0.194
Recessive model
0.92 (0.67-1.25)
0.595
0.85 (0.62-1.18)
0.341
Homozygous model
0.91 (0.76-1.09)
0.293
0.88 (0.73-1.06)
0.180
rs212704
Allele model
0.89 (0.75-1.07)
0.212
0.88 (0.73-1.06)
0.168
Dominant model
0.87 (0.67-1.14)
0.322
0.88 (0.66-1.16)
0.356
Recessive model
0.85 (0.62-1.16)
0.293
0.80 (0.58-1.11)
0.175
Homozygous model
0.89 (0.75-1.07)
0.211
0.87 (0.73-1.05)
0.153
rs675712
Allele model
0.99 (0.83-1.18)
0.873
1.00 (1.84-1.21)
0.952
Dominant model
1.00 (0.77-1.29)
0.991
1.06 (0.81-1.38)
0.694
Recessive model
0.95 (0.69-1.33)
0.777
0.93 (0.60-1.32)
0.698
Homozygous model
0.98 (0.82-1.18)
0.827
0.98 (0.81-1.19)
0.865
HT: Hashimoto’s thyroiditis; OR: odds ratio; 95% CI: 95% confidence interval; age and gender were adjusted in the multivariate logistic regression analyses.
