Research Article
Associations between NLRC4 Gene Polymorphisms and Autoimmune Thyroid Disease
Table 6
Allele frequencies and genotype distribution of NLRC4 polymorphisms with onset age in AITD patients.
| | SNPs | ≥19 years (%) | ≤18 years (%) | value | OR (95% CI) |
| | rs385076 | | | T | 1233 (63.36) | 38 (59.38) | 0.515 | 1.18 (0.71-1.97) | | C | 713 (36.64) | 26 (40.62) | | TT | 384 (39.47) | 10 (31.25) | 0.608 | — | | TC | 465 (47.79) | 18 (56.25) | | CC | 124 (12.74) | 4 (12.50) | | rs455060 | | | A | 843 (43.32) | 29 (45.31) | 0.752 | 0.92 (0.56-1.52) | | G | 1103 (56.68) | 35 (54.69) | | AA | 176 (18.09) | 5 (15.63) | 0.606 | — | | AG | 491 (50.46) | 19 (59.37) | | GG | 306 (31.45) | 8 (25.00) | | rs212704 | | | T | 840 (43.17) | 31 (48.44) | 0.402 | 0.81 (0.49-1.33) | | C | 1106 (56.83) | 33 (51.56) | | TT | 173 (17.78) | 7 (21.88) | 0.692 | — | | TC | 494 (50.77) | 17 (53.12) | | CC | 306 (31.45) | 8 (25.00) | | rs675712 | | | A | 1151 (59.15) | 33 (51.56) | 0.225 | 1.36 (0.83-2.24) | | G | 795 (40.85) | 31 (48.44) | | AA | 351 (36.07) | 10 (31.25) | 0.327 | — | | AG | 449 (46.15) | 13 (40.63) | | GG | 173 (17.78) | 9 (28.12) |
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AITD: autoimmune thyroid disease; OR: odds ratio; 95% CI: 95% confidence interval.
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