Research Article
Associations between NLRC4 Gene Polymorphisms and Autoimmune Thyroid Disease
Table 7
Allele frequencies and genotype distribution of NLRC4 polymorphisms with ophthalmopathy in GD patients.
| | SNPs | Without (%) | With (%) | value | OR (95% CI) |
| | rs385076 | | | T | 660 (62.26) | 128 (64.65) | 0.525 | 0.90 (0.657-1.239) | | C | 400 (37.74) | 70 (35.35) | | TT | 197 (37.17) | 41 (41.41) | 0.723 | — | | TC | 266 (50.19) | 46 (46.47) | | CC | 67 (12.64) | 12 (12.12) | | rs455060 | | | A | 457 (43.11) | 90 (45.45) | 0.542 | 0.91 (0.67-1.23) | | G | 603 (56.89) | 108 (54.55) | | AA | 90 (16.98) | 19 (19.19) | 0.817 | — | | AG | 277 (52.26) | 52 (52.53) | | GG | 163 (30.76) | 28 (28.28) | | rs212704 | | | T | 458 (43.21) | 88 (44.44) | 0.747 | 0.95 (0.70-1.29) | | C | 602 (56.79) | 110 (55.56) | | TT | 93 (17.55) | 18 (18.18) | 0.935 | — | | TC | 272 (51.32) | 52 (52.53) | | CC | 165 (31.13) | 29 (29.29) | | rs675712 | | | A | 631 (59.53) | 106 (53.54) | 0.116 | 1.28 (0.94-1.73) | | G | 429 (40.47) | 92 (46.46) | | AA | 197 (37.17) | 31 (31.31) | 0.296 | — | | AG | 237 (44.72) | 44 (44.44) | | GG | 96 (18.11) | 24 (24.24) |
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GD: Graves’ disease; OR: odds ratio; 95% CI: 95% confidence interval.
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