Development of Human Vectored Brucellosis Vaccine Formulation: Assessment of Safety and Protectiveness of Influenza Viral Vectors Expressing Brucella Immunodominant Proteins in Mice and Guinea Pigs
Table note: number of animals per viral construct vaccine formulation for mice was 5 or 12 and for guinea pigs was 5 per group. The amounts of substance for mice via intraperitoneal (i.p.) were 500 μl, and for guinea pigs, intranasal (i.n.) immunization was 200 μl in both nostrils. After the evaluation of protective efficacy of 18 vaccine formulations in mice, the 5 most protective vaccine formulations were selected and then tested in guinea pigs.
