Development of Human Vectored Brucellosis Vaccine Formulation: Assessment of Safety and Protectiveness of Influenza Viral Vectors Expressing Brucella Immunodominant Proteins in Mice and Guinea Pigs

Table 3

Rates of protection in guinea pigs after challenge with the virulent strain B. melitensis 16M.

Immunization group	Total animals	Isolation of B. melitensis in animals, (%)	Value ()
			(+) control	(-) control
80-Omp16	5	2 (40)	>0.05	>0.05
80-Omp16+L7/L12+Omp19+SOD	5	1 (20)	>0.05	<0.05
124-SOD	5	2 (40)	>0.05	>0.05
124-Omp16+Omp19	5	2 (40)	>0.05	>0.05
124-Omp16+L7/L12+Omp19+SOD	5	2 (40)	>0.05	>0.05
B. melitensis Rev.1	5	1 (20)	—	<0.05
Control (PBS)	5	5(100)	<0.05	—

Table note: in comparison with control untreated PBS or B. melitensis Rev.1 groups. Statistical analysis was performed using a one-sided Fisher’s exact test. <0.05: value less than 0.05; >0.05: value higher than 0.05.