Risk Factors for Hepatocellular Carcinoma Recurrence and Survival after Liver Transplantation in Patients with HCV-Related Cirrhosis
Table 2
Results of univariable Cox regressions for overall survival.
HR
95% CI
value
Age
1.02
0.97-1.08
0.378
Sex
Female
—
—
—
Male
0.68
0.31-1.50
0.336
Transplantation waiting time
1.00
1.00-1.00
0.483
Child-Pugh classification
Child-Pugh stage A
—
—
—
Child-Pugh stage B
1.27
0.55-2.95
0.572
Child-Pugh stage C
0.50
0.16-1.59
0.240
MELD score
1.00
0.92-1.09
0.990
Alpha-fetoprotein a
1.01
1.00-1.02
0.018
Previous locoregional treatment for HCC
1.55
0.67-3.57
0.307
Number of HCC lesions
Single tumor
—
—
—
2-3 tumors
1.59
0.58-4.40
0.370
4-5 tumors
1.54
0.40-5.99
0.530
>5 tumors
1.05
0.38-2.89
0.931
Total tumor size
<5 cm
—
—
—
5-9 cm
0.88
0.25-3.10
0.846
>9 cm
1.05
0.46-2.39
0.913
Incidental HCC diagnosed postoperatively
0.59
0.24-1.48
0.265
Microvascular invasion
0.53
0.13-2.27
0.395
Presence of tumor necrosis
1.44
0.66-3.15
0.355
>4 red blood cells units transfused during transplantation
4.06
1.86-8.86
<0.001
aThe results reported here for alpha-fetoprotein levels correspond to increases of 100 units of alpha-fetoprotein levels; i.e., the hazard ratio of 1.01 means that every increase of 100 ng/ml is associated with a 1% increase in the hazard of death. HCC: hepatocellular carcinoma; MELD: model for end-stage liver disease.
