Risk Factors for Hepatocellular Carcinoma Recurrence and Survival after Liver Transplantation in Patients with HCV-Related Cirrhosis
Table 3
Results of simple cause-specific Cox regressions for hepatocellular carcinoma recurrence.
HR
95% CI
value
Age
0.96
0.89-1.05
0.403
Sex
Female
Male
3.71
0.47-28.97
0.212
Transplantation waiting time
1.00
1.00-1.00
0.573
Child-Pugh classification
Child-Pugh stage A
Child-Pugh stage B
2.41
0.62-9.32
0.202
Child-Pugh stage C
0.50
0.05-4.81
0.549
MELD score
0.92
0.80-1.06
0.262
Alpha-fetoprotein
1.00
0.99-1.01
0.746
Received previous locoregional treatment for HCC
1.28
0.37-4.37
0.695
Number of HCC lesions
Single tumor
2-3 tumors
2.58
0.23-28.49
0.439
4-5 tumors
9.05
0.81-100.45
0.073
>5 tumors
5.81
0.70-48.30
0.103
Total tumor size
<5 cm
5-9 cm
3.76
0.62-22.64
0.149
>9 cm
3.04
0.76-12.15
0.116
Incidental HCC diagnosed postoperatively
1.13
0.33-3.87
0.842
Microvascular invasion
14.86
4.47-49.39
<0.001
Presence of tumor necrosis
1.44
0.41-5.12
0.569
>4 red blood cells units transfused during transplantation
1.30
0.35-4.92
0.695
aThe results reported for alpha-fetoprotein levels correspond to increases of 100 units of alpha-fetoprotein levels; i.e., the hazard ratio of 1.01 means that every increase of 100 ng/ml is associated with a 1% increase in the hazard of hepatocellular carcinoma recurrence. HCC: hepatocellular carcinoma; MELD: model for end-stage liver disease.
