Research Article
Jiao-Tai-Wan Ameliorates Depressive-Like Behavior through the A1R Pathway in Ovariectomized Mice after Unpredictable Chronic Stress
| | Days | 1 | 2 | 3 | 4 | 5 | 6 | 7 | | Stressors | Food deprivation (24 h) | Water deprivation (24 h) | Cold swim (10°C, 5 min) | Shaking (high speed, 45 min) | Food deprivation (24 h) | Tail pinch (1 min) | Water deprivation (24 h) | | Restraint (4 h) | Tail pinch (1 min) | Wet sawdust (4 h) | Lights on overnight (6 h) | Social isolation (6 h) | Cold swim (6°C, 8 min) | Shaking (high speed, 1 h) | | Days | 8 | 9 | 10 | 11 | 12 | 13 | 14 | | Stressors | Foot shock (30 min; 1 mA, 1 s duration average 1 shock/min) | Food deprivation (24 h) | Lights on overnight (12 h) | Tail pinch (1 min) | Water deprivation (24 h) | Foot shock (45 min; 1 mA, 1 s duration average 1 shock/min) | Food deprivation (24 h) | | Restraint (6 h) | Social isolation (24 h) | Wet sawdust (6 h) | Cold swim (4°C, 10 min) | Switching cages (8 h) | Shaking (high speed, 1.5 h) | Wet sawdust (8 h) |
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