Effects of Dexmedetomidine on the Pharmacokinetics of Parecoxib and Its Metabolite Valdecoxib in Beagles by UPLC-MS/MS

Table 1

Precision and accuracy of two analytes in beagle plasma (, ).

Compound	Added (ng/mL)	Intraday			Interday
		Found (ng/mL)	RSD (%)	RE (%)	Found (ng/mL)	RSD (%)	RE (%)
Parecoxib	10		7.27	-1.20		8.07	-0.30
	500		5.48	2.76		6.79	0.69
	3000		3.34	2.05		3.56	0.96
Valdecoxib	10		6.47	-0.60		7.17	0.70
	500		4.98	-0.59		6.49	1.66
	3000		3.97	2.66		3.46	1.50