Effects of Dexmedetomidine on the Pharmacokinetics of Parecoxib and Its Metabolite Valdecoxib in Beagles by UPLC-MS/MS

Table 4

The stock solution stability of parecoxib, valdecoxib, and IS in beagle plasma ().

Compounds	Spiked (μg/mL)	Room temperature, 12 h		-20°C, 3 weeks
		RSD (%)	RE (%)	RSD (%)	RE (%)
Parecoxib	10	3.80	-0.67	4.13	0.83
Valdecoxib	10	3.43	0.33	4.31	-2.17
IS	10	3.95	-2.17	4.20	-1.83