Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population

Table 1

Basic characteristics of subjects.

Variables	Baseline measurements				Measurements at 3700 m
	Total (580)	HAH+ (421)	HAH− (159)	value^a	Total (580)	HAH+ (421)	HAH− (159)	value^a	value^#
Basic demographic data
Age (year)	23.04 ± 3.71	23.22 ± 3.89	22.58 ± 3.12	0.067	23.04 ± 3.71	23.22 ± 3.89	22.58 ± 3.12	0.067	—
Height (cm)	171.49 ± 4.64	171.42 ± 4.64	171.67 ± 4.64	0.571	171.49 ± 4.64	171.42 ± 4.64	171.67 ± 4.64	0.571	—
Weight (kg)	64.09 ± 7.42	64.19 ± 7.74	63.84 ± 6.50	0.615	64.09 ± 7.42	64.19 ± 7.74	63.84 ± 6.50	0.615	—
BMI (kg/m^2)	21.78 ± 2.20	21.82 ± 2.29	21.65 ± 1.94	0.410	21.78 ± 2.20	21.82 ± 2.29	21.65 ± 1.94	0.410	—
Current smokers	311 (53.62)	215 (51.07)	96 (60.38)	0.045^b	311 (53.62)	215 (51.07)	96 (60.38)	0.045^b	—
Current drinkers	25 (4.31)	15 (3.56)	10 (6.29)	0.149^b	25 (4.31)	15 (3.56)	10 (6.29)	0.149^b	—
Physiological parameters
HR (bpm)	65.17 ± 10.39	65.17 ± 10.63	65.17 ± 9.78	0.997	85.53 ± 12.97	86.33 ± 13.44	83.43 ± 11.42	0.016	<0.001
SpO2 (%)	98.14 ± 1.00	98.13 ± 1.02	98.19 ± 0.95	0.562	88.47 ± 3.14	88.25 ± 3.20	89.04 ± 2.91	0.007	<0.001
SBP (mmHg)	115.89 ± 10.83	115.91 ± 10.85	115.83 ± 10.82	0.945	118.39 ± 11.41	118.74 ± 11.85	117.45 ± 10.13	0.225	<0.001
DBP (mmHg)	73.81 ± 9.48	74.25 ± 9.76	72.64 ± 8.60	0.117	78.78 ± 9.83	79.23 ± 10.01	77.61 ± 9.26	0.077	<0.001

^aIndependent samples t-test. ^bChi-squared test (2 2 contingency table, df = 1). indicated statistical significance. ^#Comparison of physiological parameters between baseline and measurements at 3700 m in all subjects. HAH+, subjects with HAH; HAH−, subjects without HAH. HAH, high-altitude headache; BMI, body mass index; HR, heart rate; SpO₂, pulse oxygen saturation; SBP, systolic blood pressure; DBP, diastolic blood pressure.