BioMed Research International / 2020 / Article / Tab 3

Research Article

Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population

Table 3

Association between SNPs in EPAS1 and HAH under multiple genetic models.

SNPModelAllele/genotypeHAH+ [n (%)]HAH− [n (%)]OR (95% CI) valueOR (95% CI)a valuea

rs4953354AlleleA749 (89.0)264 (83.0)0.007
G93 (11.0)54 (17.0)
CodominantAA331 (78.6)109 (68.5)10.02310.046
AG87 (20.7)46 (28.9)0.62 (0.41–0.95)0.61 (0.40–0.94)
GG3 (0.7)4 (2.5)0.25 (0.05–1.12)0.37 (0.08–1.74)
DominantAA331 (78.6)109 (68.5)10.01310.016
AG/GG90 (21.4)50 (31.4)0.59 (0.39–0.89)0.59 (0.39–0.90)
RecessiveAA/AG418 (99.3)155 (97.5)10.09710.250
GG3 (0.7)4 (2.5)0.28 (0.06–1.26)0.41 (0.09–1.93)

rs6756667AlleleG758 (90.0)270 (84.9)0.014
A84 (10.0)48 (15.1)
CodominantGG339 (80.5)115 (72.3)10.03010.061
AG80 (19)40 (25.2)0.68 (0.44–1.05)0.67 (0.43–1.05)
AA2 (0.5)4 (2.5)0.17 (0.03–0.94)0.23 (0.04–1.29)
DominantGG339 (80.5)115 (72.3)10.03610.044
AG/AA82 (19.5)44 (27.7)0.63 (0.41–0.97)0.64 (0.41–0.98)
RecessiveGG/AG419 (99.5)155 (97.5)10.04410.100
AA2 (0.5)4 (2.5)0.18 (0.03–1.02)0.25 (0.04–1.41)

Allelic frequencies were compared by the Chi-squared test (2 2 contingency table, df = 1). Association between SNPs and HAH under different models was detected by using binary logistic regression. aAdjusted for age, height, weight, BMI, smoking and drinking status, HR, SpO2, SBP, and DBP. indicated statistical significance. HAH+, subjects with HAH; HAH−, subjects without HAH. OR, odds ratio; 95% CI, 95% confidence interval; SNP, single nucleotide polymorphism; HAH, high-altitude headache; BMI, body mass index; HR, heart rate; SpO2, pulse oxygen saturation; SBP, systolic blood pressure; DBP, diastolic blood pressure.