Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population

Table 3

Association between SNPs in EPAS1 and HAH under multiple genetic models.

SNP	Model	Allele/genotype	HAH+ [n (%)]	HAH− [n (%)]	OR (95% CI)	value	OR (95% CI)^a	value^a
rs4953354	Allele	A	749 (89.0)	264 (83.0)		0.007
		G	93 (11.0)	54 (17.0)
	Codominant	AA	331 (78.6)	109 (68.5)	1	0.023	1	0.046
		AG	87 (20.7)	46 (28.9)	0.62 (0.41–0.95)		0.61 (0.40–0.94)
		GG	3 (0.7)	4 (2.5)	0.25 (0.05–1.12)		0.37 (0.08–1.74)
	Dominant	AA	331 (78.6)	109 (68.5)	1	0.013	1	0.016
		AG/GG	90 (21.4)	50 (31.4)	0.59 (0.39–0.89)		0.59 (0.39–0.90)
	Recessive	AA/AG	418 (99.3)	155 (97.5)	1	0.097	1	0.250
		GG	3 (0.7)	4 (2.5)	0.28 (0.06–1.26)		0.41 (0.09–1.93)
rs6756667	Allele	G	758 (90.0)	270 (84.9)		0.014
		A	84 (10.0)	48 (15.1)
	Codominant	GG	339 (80.5)	115 (72.3)	1	0.030	1	0.061
		AG	80 (19)	40 (25.2)	0.68 (0.44–1.05)		0.67 (0.43–1.05)
		AA	2 (0.5)	4 (2.5)	0.17 (0.03–0.94)		0.23 (0.04–1.29)
	Dominant	GG	339 (80.5)	115 (72.3)	1	0.036	1	0.044
		AG/AA	82 (19.5)	44 (27.7)	0.63 (0.41–0.97)		0.64 (0.41–0.98)
	Recessive	GG/AG	419 (99.5)	155 (97.5)	1	0.044	1	0.100
		AA	2 (0.5)	4 (2.5)	0.18 (0.03–1.02)		0.25 (0.04–1.41)

Allelic frequencies were compared by the Chi-squared test (2 2 contingency table, df = 1). Association between SNPs and HAH under different models was detected by using binary logistic regression. ^aAdjusted for age, height, weight, BMI, smoking and drinking status, HR, SpO₂, SBP, and DBP. indicated statistical significance. HAH+, subjects with HAH; HAH−, subjects without HAH. OR, odds ratio; 95% CI, 95% confidence interval; SNP, single nucleotide polymorphism; HAH, high-altitude headache; BMI, body mass index; HR, heart rate; SpO₂, pulse oxygen saturation; SBP, systolic blood pressure; DBP, diastolic blood pressure.