Role of Oxidation-Dependent CaMKII Activation in the Genesis of Abnormal Action Potentials in Atrial Cardiomyocytes: A Simulation Study

Figure 4

Frequency-dependent activation of CaMKII. (a) CaMKII activation curves at 0.5, 1, and 2 Hz in 80 s. (b) Normalized CaMKII activation, RyR calcium release (RyR Activity), and intracellular Ca²⁺ transient (CaT) to 2 Hz at 0.5, 1, and 2 Hz.

(a)

(b)