Research Article
Mechanism of YuPingFeng in the Treatment of COPD Based on Network Pharmacology
Table 4
Information on hub genes.
| Gene symbol | Gene name | Degree | Closeness |
| IL-6 | Interleukin-6 | 50 | 64.33333 | CASP3 | Caspase-3 | 48 | 63.33333 | MAPK8 | Mitogen-activated protein kinase 8 | 47 | 62.5 | VEGF-A | Vascular endothelial growth factor A | 47 | 62.5 | EGFR | Epidermal growth factor receptor | 46 | 62.16667 | MYC | Myc protooncogene protein | 45 | 61.5 | ESR1 | Estrogen receptor | 44 | 61 | CCND1 | G1/S-specific cyclin-D1 | 42 | 60 | FOS | Protooncogene c-Fos | 38 | 58.5 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | 36 | 56.83333 | AR | Androgen receptor | 34 | 56 | RELA | Transcription factor p65 | 32 | 55.5 | PPARG | Peroxisome proliferator activated receptor gamma | 32 | 55 | NOS3 | Nitric oxide synthase, endothelial | 29 | 53.83333 | PGR | Progesterone receptor | 28 | 53 | CASP8 | Caspase-8 | 27 | 52 | CAV1 | Caveolin-1 | 26 | 51.5 | AHR | Aryl hydrocarbon receptor | 25 | 51.16667 | ICAM1 | Intercellular adhesion molecule 1 | 24 | 51 | HIF-1α | Hypoxia-inducible factor 1-alpha | 24 | 51 | CASP9 | Caspase-9 | 24 | 50.66667 | RB1 | Retinoblastoma-associated protein | 22 | 49.66667 | CYP3A4 | Cytochrome P450 3A4 | 21 | 49.5 | NFE2L2 | Nuclear factor erythroid 2-related factor 2 | 21 | 49.33333 | NFKBIA | NF-kappa-B inhibitor alpha | 20 | 48.66667 | NQO1 | NAD(P)H dehydrogenase [quinone] 1 | 20 | 48.33333 |
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