Research Article
The Effect of Grapefruit Juice on the Pharmacokinetics of Tadalafil in Rats
Table 4
The main pharmacokinetic parameters of tadalafil after oral administration of 5 mg/kg tadalafil in rat plasma (means ± SD, n = 6).
| Parameters | Group A (tadalafil + grapefruit juice) | Group B (tadalafil) |
| t1/2 (h) | 11.70 ± 1.47 | 9.28 ± 2.07 | Tmax (h) | 1.25 ± 0.27 | 1.25 ± 0.27 | Cmax (ng/mL) | 1271.60 ± 179.31 | 725.89 ± 161.59 | AUC(0-t) (ng·h/mL) | 9586.52 ± 2048.81 | 7399.61 ± 696.85 | AUC(0-∞) (ng·h/mL) | 10639.43 ± 2235.94 | 7995.50 ± 707.23 | CLz/F (L/h/kg) | 0.50 ± 0.14 | 0.63 ± 0.06 | Vdz/F (L/kg) | 8.42 ± 2.96 | 8.48 ± 2.25 |
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