The Effect of Grapefruit Juice on the Pharmacokinetics of Tadalafil in Rats

Table 4

The main pharmacokinetic parameters of tadalafil after oral administration of 5 mg/kg tadalafil in rat plasma (means ± SD, n = 6).

Parameters	Group A (tadalafil + grapefruit juice)	Group B (tadalafil)
t1/2 (h)	11.70 ± 1.47	9.28 ± 2.07
Tmax (h)	1.25 ± 0.27	1.25 ± 0.27
Cmax (ng/mL)	1271.60 ± 179.31	725.89 ± 161.59
AUC(0-t) (ng·h/mL)	9586.52 ± 2048.81	7399.61 ± 696.85
AUC(0-∞) (ng·h/mL)	10639.43 ± 2235.94	7995.50 ± 707.23
CLz/F (L/h/kg)	0.50 ± 0.14	0.63 ± 0.06
Vdz/F (L/kg)	8.42 ± 2.96	8.48 ± 2.25