TRAF2 Knockdown in Nasopharyngeal Carcinoma Induced Cell Cycle Arrest and Enhanced the Sensitivity to Radiotherapy

<div>TRAF2 played a crucial role in NPC cells. (a) The expression of TRAF2 in normal nasopharyngeal epithelial cell NP460 and nine NPC cells was examined by western blotting. (b) TRAF2 knockdown inhibited NPC cell proliferation. TRAF2 deficient CNE1 (left) or HK-1(right) cells were established with shRNA as described, and the cell proliferation rate at different time points was examined by MTS assays. The efficiency of shRNA was confirmed by western blotting. (c) TRAF2-shRNA suppressed the NPC colony formation in soft agar. CNE1 (upper) or HK-1 (below) cells transfected with shRNA and the anchorage-independent growth assays were performed as described. 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BioMed Research International

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Figure 1

Figure 1: TRAF2 Knockdown in Nasopharyngeal Carcinoma Induced Cell Cycle Arrest and Enhanced the Sensitivity to Radiotherapy 