Differential Expression and Prognostic Value of Cytoplasmic and Nuclear Cyclin D1 in Prostate Cancer

Table 3

Univariate and multivariate analyses of CCND1 expression in BCR-free survival time analysis.

Univariate	BCR-free survival time
	HR (95% CI)
Low IE score (cytoplasmic)	1
High IE score (cytoplasmic)	0.536 (0.362-0.793)	0.002
Low IE score (nuclear)	1
High IE score (nuclear)	0. 816 (0.561-1.186)	0.286
Multivariate
IE score (cytoplasmic) (low/high)	0.774 (0.504-1.189)	0.242
pT stage (pT2/pT3, pT4)	1.736 (1.128-2.672)	0.012
pN stage (pNx, pN0/pN1)	2.560 (1.576-4.159)	<0.001
Gleason score ()	2.011 (1.337-3.026)	0.001
PSA level ()	2.096 (1.147-3.829)	0.016