HLA-G Polymorphisms Associated with HIV Infection and Preeclampsia in South Africans of African Ancestry

Table 5

Allelic frequencies.

	Normotensive			Preeclampsia									Normotensive vs. preeclampsia
Polymorphisms	HIV-; ()	HIV+; ()	HIV- vs. HIV+; OR (95%), value	HIV-; ()	HIV +; ()	HIV- vs. HIV+; OR (95%), value	HIV- EOPE; ()	HIV+ EOPE; ()	HIV- vs. HIV+; OR (95%), value	HIV- LOPE; ()	HIV+ LOPE; ()	HIV- LOPE vs. HIV+ LOPE; OR (95%), value	HIV+ normotensive vs. HIV+ PE; OR (95%), value	HIV- normotensive vs. HIV- PE; OR (95%), value
SNP 3022 (rs1707)
T; T vs. C	130 (87.83%)	95 (79.16%)	5.313 (1.408-20.04)	61 (89.70%)	42 (84%)	2.051 (0.6106-6.890)	21 (80.76%)	30 (78.94%)	2.121 (0.4328-10.40)	39 (92.85%)	7 (58.33%)	20.50 (2.02-208.4)	1.617 (0.6491-4.026)	1.745 (0.6193-4.915)
G; G vs. C	84 (56.75%)	65 (54.16%)	1.111 (0.6841-1.803)	42 (61.76%)	30 (60%)	1.077 (0.5097-2.275)	16 (61.53%)	20 (52.63%)	1.108 (0.4104-2.990)	26 (61.90%)	8 (66.66%)	1.538 (0.4124-5.739)	1.269 (0.6493-2.481)	1.231 (0.6840-2.215)
SNP 3161(rs1063320)
G; G vs. C	81 (54.72%)	75 (62.5%)	1.379 (0.8434-2.253)	34 (50%)	30 (60%)	1.500 (0.7163-3.141)	14 (53.84%)	24 (63.15%)	1.440 (0.5219-3.974)	20 (47.61%)	6 (50%)	1.538 (0.4124-5.739)	1.111 (0.5652-2.184)	1.209 (0.6801-2.149)
SNP 3206 (rs9380142)
A; A vs. G	120 (81.08%)	104 (86.66%)	1.633 (0.8276-3.223)	47 (69.11%)	46 (92%)	10.72 (2.380-48.32)	21 (80.76%)	34 (89.47%)	2.348 (0.3638-15.15)	24 (57.14%)	9 (75%)	9.00 (1.07-75.74)	3.429 (0.7538-15.59)	1.915 (0.9909-3.701)
SNP 3215 (rs1610696)
C; C vs. G	88 (59.45%)	65 (54.16%)	1.221 (0.7512-1.984)	56 (82.35%)	33 (66%)	2.67 (1.12-6.38)	22 (84.61%)	25 (65.78%)	4.15 (1.05-16.50)	33 (78.57%)	7 (58.33%)	1.500 (0.3544-6.349)	9.000 (0.9813-82.54)	21.91 (2.84-169.0)

Asterisks denote significance: , , and . SNP=single nucleotide polymorphisms, Del=deletion, Ins=insertion, HIV- =HIV uninfected, HIV+ =HIV infected, EOPE=early-onset preeclampsia, and LOPE=late-onset preeclampsia.