Aspirin and Risk of Dementia in Patients with Late-Onset Depression: A Population-Based Cohort Study

Table 1

Characteristics of aspirin users and non-users among patients with LOD ().

		Aspirin nonuser		Aspirin user		-value
		(41.9%)		(58.1%)
Age (years)	Mean (SD)	72.47	(5.74)	73.58	(5.67)	<0.001
Gender	F	1,451	(59.9)	2,007	(55.7)	0.001
	M	973	(40.1)	1,597	(44.3)
COPD	No	1,210	(49.9)	1,453	(40.3)	<0.001
	Yes	1,214	(50.1)	2,151	(59.7)
DM	No	1,734	(71.5)	1,985	(55.1)	<0.001
	Yes	690	(28.5)	1,619	(44.9)
HTN	No	708	(29.2)	255	(7.1)	<0.001
	Yes	1,716	(70.8)	3,349	(92.9)
IHD	No	1,693	(69.8)	1,125	(31.2)	<0.001
	Yes	731	(30.2)	2,479	(68.8)
CHF	No	2,009	(82.9)	2,331	(64.7)	<0.001
	Yes	415	(17.1)	1,273	(35.3)
CVA	No	1,842	(76.0)	1,635	(45.4)	<0.001
	Yes	582	(24.0)	1,969	(54.6)
CRI	No	2,151	(88.7)	3,038	(84.3)	<0.001
	Yes	273	(11.3)	566	(15.7)
Follow-up duration (year)	Mean ± SD	5.8 ± 3.52		6.18 ± 3.46		<0.001

CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; CRI, chronic renal insufficiency; CVA, cerebrovascular accident; DM, diabetes mellitus; HTN, hypertension; IHD, ischemic heart disease; LOD, late-onset depression; SD, standard deviation. The t-test was used to comparing the means of age and duration. Categorical variables (gender, COPD, DM, HTN, IHD, CHF, CVA, CRI, and dementia) were compared using the Chi-square test between patients.