Aspirin and Risk of Dementia in Patients with Late-Onset Depression: A Population-Based Cohort Study

Table 3

Risk factors for subsequent dementia in LOD patients as determined using a multivariate time to dependent Cox proportional hazards model ().

	Hazard ratios	95% CI	-value
Aspirin
Yes vs. No	0.734	(0.641–0.841)	<0.001
Age
Elder vs. younger	1.064	(1.054–1.074)	<0.001
Gender
Female vs. male	1.211	(1.073–1.366)	0.002
DM
Yes vs. No	1.142	(1.012–1.289)	0.032
HTN
Yes vs. No	1.237	(1.018–1.503)	0.032
COPD
Yes vs. No	1.268	(1.119–1.437)	<0.001
CRI
Yes vs. No	1.063	(0.906–1.247)	0.453
IHD
Yes vs. No	1.064	(0.935–1.211)	0.348
CHF
Yes vs. No	0.939	(0.821–1.072)	0.351
CVA
Yes vs. No	1.684	(1.487–1.907)	<0.001

CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; CRI, chronic renal insufficiency; CVA, cerebrovascular accident; DM, diabetes mellitus; HTN, hypertension; IHD, ischemic heart disease; LOD, late-onset depression.