CDKL2 Is Associated with HER2 Status and Overall Survival in Gastric Cancer: Comparative Analysis of CDKL2 Protein Expression and Gene Copy Number

Figure 4

Higher CDKL2 H-score and copy number both predicted worse OS of GC patients. (a) GC patients with higher CDKL2 H-score had a shorter OS than those with lower H-score ( (1.38–2.82), ). (b) GC patients with higher CDKL2 copy number had a worse OS than those with lower CDKL2 copy number ( (1.12–3.39), ). (c) The patients with higher CDKL2 H-score or higher CDKL2 copy number had a poorer OS than those with both lower CDKL2 H-score and lower CDKL2 copy number ( (1.21–2.65), ); the patients with both higher CDKL2 H-score and higher CDKL2 copy number had an even lower OS than those with both lower CDKL2 H-score and lower CDKL2 copy number (HR =2.41 (1.74–7.17), ). (d) Data from TCGA showed that GC patients with higher CDKL2 mRNA level had significantly shorter OS than those with lower CDKL2 mRNA level (26.5 vs. 46.9 months, (1.01–1.92), ; the median was set as cut-off point).

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