Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on T Cell Differentiation in Primary Biliary Cholangitis

Figure 2

DCs are activated through AhR agonists TCDD. DCs from HCs and PBC patients were treated with 10 nM TCDD (TCDD group) and 10 μM CH223191+10 nM TCDD (CH+TCDD group) for 48 h and stained for MHC II, CD86, CD80, and CD40 mAbs analyzed by FACS. The differences of MFI of MHC II (a), CD86 (b), CD80 (c), and CD40 (d) were analyzed in different groups by statistical analysis (e). In both the healthy control and PBC patients, compared to the blank control and CH+TCDD group, the MFI of MHC II, CD86, CD80, and CD40 were increased. Results are presented as . Significantly higher than the control, (, , and ).