Combinational Use of Antiplatelet Medication Sarpogrelate with Therapeutic Drug Rosuvastatin in Treating High-Cholesterol Diet-Induced Chronic Kidney Disease in ApoE-Deficient Mice

Figure 3

Detection of alterations of lipid homeostasis and pathological heterogeneity under each condition. (a) Relative mRNA expression of LDL-R, CD36, LOX-1, and ABCA1 was evaluated by qPCR in the kidney tissues of mice following an 8-week treatment under each condition ( in each group). (b) Representative images and quantifications of Western blot analysis showing the LOX-1 expression level in kidney tissues of mice following an 8-week treatment under each condition. Scale bar, 200 mm (–4 in each group). (c) Representative images and quantification of immunohistochemistry showing the LOX-1 expression level in kidney tissues of mice following an 8-week treatment under each condition. Scale bar, 200 mm (–4 in each group). Data were expressed as ; vs. ApoE^−/− HD, ^# vs. ApoE^−/− HD+R.

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