Research Article
Identification, Validation, and Functional Annotations of Genome-Wide Profile Variation between Melanocytic Nevus and Malignant Melanoma
Table 1
Clinicopathological characteristics of the patients from two cohorts.
| | Characteristics | FAHSU cohort | TCGA cohort () | | Nevi () | Melanoma () |
| | (%) | | Age | | ≤60 years | 23 (74.2) | 13 (41.9) | 258 (54.7) | | >60 years | 8 (25.8) | 18 (58.1) | 214 (45.3) | | Gender | | Male | 14 (45.2) | 20 (64.5) | 297 (61.9) | | Female | 17 (54.8) | 11 (35.5) | 183 (38.1) | | Location | | Extremity | 21 (67.7) | 24 (77.4) | — | | Trunk | 10 (32.3) | 7 (22.6) | — | | Clark level | | I | — | 13 (41.9) | 6 (1.8) | | II | — | 15 (48.4) | 18 (5.5) | | III–IV | — | 3 (9.7) | 246 (75.5) | | V | — | 0 (0) | 56 (17.2) | | Breslow’s depth (mm) | | ≤0.75 | — | 5 (16.1) | 36 (10.2) | | 0.76-1.50 | — | 10 (32.2) | 65 (18.4) | | 1.51-4.00 | — | 13 (41.9) | 106 (30.0) | | >4.00 | — | 3 (9.8) | 146 (41.4) | | pT stage | | T1-T2 | — | 19 (61.3) | 121 (32.7) | | T3-T4 | — | 12 (38.7) | 249 (67.3) | | pN stage | | N0 | — | 31 (100) | 236 (65.0) | | N1 | — | 0 (0) | 75 (20.7) | | N2 | — | 0 (0) | 52 (14.3) | | pM stage | | M0 | — | 31 (100) | 424 (94.4) | | M1 | — | 0 (0) | 25 (5.6) | | Pathologic stage | | I-II | — | 31 (100) | 233 (53.9) | | III-IV | — | 0 (0) | 199 (46.1) | | Persistent distant metastasis | | No | — | 31 (100) | 217 (46.1) | | Yes | — | 0 (0) | 254 (53.9) | | Cell atypia/atypical hyperplasia | | No | 31 (100) | — | — | | Yes | 0 (0) | — | — |
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FAHSU: the First Affiliated Hospital of Soochow University; TCGA: The Cancer Genome Atlas.
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