Anti-Inflammatory and Antioxidant Effect of Eucommia ulmoides Polysaccharide in Hepatic Ischemia-Reperfusion Injury by Regulating ROS and the TLR-4-NF-κB Pathway

Figure 7

EUP inhibits activation of the NF-κB pathway induced by liver I/R. Protein expression of MyD88 (a), TRAF6 (b), p65 (c), phospho-p65 (d), IKB-α (e), and phospho-IKB-α (f) were detected by Western blot, and the data are expressed as . Compared with the I/R group, the protein expression levels of MyD88, TRAF6, p65, phospho-p65, and phospho-IKB-α were significantly decreased in the EUP high-dose group, and the protein expression of IKB-α was significantly elevated in the EUP high-dose group. The results showed that EUP could significantly inhibit the phosphorylation of IKB-α and p65, thereby reducing the inflammatory response (^★compared with the I/R group, ).

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