Employment of Alginate Floating In Situ Gel for Controlled Delivery of Celecoxib: Solubilization and Formulation Studies

Table 4

Results of curve fitting of the in vitro diclofenac sodium release data from different optimized alginate-PVP K30 microbeads.

Formula code	Zero-order kinetics		First-order kinetics		Higuchi model	Korsmeyer-Peppas model
	(% h^-1)		(h^-1)		(% h^-1/2)		(% h^-1)
F1	4.456	0.625	0.097	0.4286	24.116	0.6332	45.245	0.216	0.505
F2	2.547	0.167	0.086	0.019	24.087	0.6536	41.264	0.325	0.601
F3	2.308	0.209	0.027	0.5793	22.105	0.9877	25.687	0.494	0.886