RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation

<div>RCAN1 increases BACE2 expression. (a) HEK293 cells and HRNLM cells were cotransfected with plasmids pEGFP and pBACE2-mycHis. Cell lysates were resolved by 10% SDS-PAGE. BACE2 expression was detected by using 9E10 antibody. GFP was detected by GFP antibody. Anti-RCAN1 antibody was used to detect RCAN1. <i>β</i>-Actin was detected by AC-15 antibody. (b) Quantification of BACE2 levels. GFP levels were used to normalize the transfection efficiency. 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BioMed Research International

fig1

Figure 1

Figure 1: RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation 