Identification of ATP8B1 as a Tumor Suppressor Gene for Colorectal Cancer and Its Involvement in Phospholipid Homeostasis
Table 1
Patient demographics.
Discovery dataset (TCGA CRC, )
Validation dataset (GSE39582, )
Gender
Male
194 (54%)
310 (55%)
Female
165 (46%)
256 (45%)
Age (years)
Median (IQR)
66 (55-74.5)
68.1 (59-76)
>65 vs. ≤65
184 vs. 175
342 vs. 124
Stage
I
56
37
II
134
264
III
116
205
IV
53
60
KRAS status
Wild type
217 (60%)
328 (58%)
Mutant
142 (40%)
217 (39%)
N/A
—
21 (3%)
BRAF status
Wild type
307 (86%)
461 (82%)
Mutant
52 (14%)
51 (9%)
N/A
—
54 (9%)
TP53 status
Wild type
140 (39%)
161 (28%)
Mutant
219 (61%)
190 (34%)
N/A
—
215 (38%)
OS
Median
22.4 (months)
51 (months)
Range
0-150 (months)
0-201 (months)
Event/nonevent
77/282
191/371
PFI or RFS
Median
19.6 (months)
43 (months)
Range
0-150 (months)
0-201 (months)
Event/nonevent
100/259
177/380
Stage I group included four stage 0 cases in the GSE38582 dataset. PFI (progress-free interval) was provided in the TCGA CRC cohort, while RFS (relapse-free survival) was obtained in GSE38582.
