Identification of ATP8B1 as a Tumor Suppressor Gene for Colorectal Cancer and Its Involvement in Phospholipid Homeostasis

Table 2

Univariate and multivariate analyses of factors associated with overall survival and progress-free interval in the TCGA CRC cohort.

	Univariate analysis^b		Multivariate analysis^b
	HR (95% CI)	value^a	HR (95% CI)	value^a
TCGA CRC/OS ()
Gender (male vs. female)	1.143 (0.83-1.574)	0.412
Age (≤65 vs. >65)	0.586 (0.415-0.827)	0.002	0.522 (0.369-0.739)	<0.001
Stage (III-IV vs. I-II)	2.077 (1.484-2.908)	<0.001	2.058 (1.457-2.906)	<0.001
KRAS (wild type vs. mutant)	1.125 (0.812-1.558)	0.479
BRAF (wild type vs. mutant)	0.842 (0.552-1.285)	0.425
TP53 (wild type vs. mutant)	0.65 (0.456-0.927)	0.017	0.774 (0.536-1.119)	0.173
ATP8B1 expression (low vs. high)	1.743 (1.247-2.435)	0.001	1.512 (1.069-2.137)	0.019
TCGA CRC/PFI ()
Gender (male vs. female)	1.292 (0.97-1.722)	0.08
Age (≤65 vs. >65)	1.168 (0.884-1.542)	0.275
Stage (III-IV vs. I-II)	2.132 (1.587-2.864)	<0.001	2.029 (1.509-2.729)	<0.001
KRAS (wild type vs. mutant)	0.873 (0.66-1.154)	0.339
BRAF (wild type vs. mutant)	1.315 (0.828-2.087)	0.246
TP53 (wild type vs. mutant)	0.798 (0.595-1.07)	0.131
ATP8B1 expression (low vs. high)	1.739 (1.298-2.331)	<0.001	1.62 (1.207-2.174)	0.001

^aCohorts were calculated using the Cox proportional hazards regression model. Bold indicates statistically significant values. ^bMultivariate analysis used the covariates associated with survival in univariate models (). The Wald statistic was applied to test whether the covariates were independent variables (). Bold indicates statistically significant values.