Identification of ATP8B1 as a Tumor Suppressor Gene for Colorectal Cancer and Its Involvement in Phospholipid Homeostasis

Table 3

Univariate and multivariate analyses of factors associated with overall survival and relapse-free survival in the GSE39582 cohort.

	Univariate analysis^b		Multivariate analysis^b
	HR (95% CI)	value^a	HR (95% CI)	value^a
GSE39582/OS ()
Gender (male vs. female)	1.21 (0.986-1.486)	0.068
Age (≤65 vs. >65)	0.763 (0.616-0.945)	0.013	0.748 (0.602-0.93)	0.009
Stage (III-IV vs. I-II)	1.496 (1.221-1.832)	<0.001	1.483 (1.205-1.825)	<0.001
KRAS (wild type vs. mutant)	0.804 (0.655-0.987)	0.037	0.823 (0.67-1.011)	0.063
BRAF (wild type vs. mutant)	0.928 (0.645-1.336)	0.688
TP53 (wild type vs. mutant)	0.881 (0.688-1.127)	0.313
ATP8B1 expression (low vs. high)	1.297 (1.028-1.638)	0.028	1.207 (0.953-1.53)	0.119
GSE39582/RFS ()
Gender (male vs. female)	1.182 (0.956-1.463)	0.123
Age (≤65 vs. >65)	1.117 (0.905-1.379)	0.301
Stage (III-IV vs. I-II)	2.067 (1.658-2.577)	<0.001	1.934 (1.546-2.421)	<0.001
KRAS (wild type vs. mutant)	0.781 (0.63-0.967)	0.023	0.814 (0.657-1.008)	0.06
BRAF (wild type vs. mutant)	1.051 (0.703-1.572)	0.809
TP53 (wild type vs. mutant)	0.804 (0.627-1.031)	0.085
ATP8B1 expression (low vs. high)	1.541 (1.153-2.059)	0.003	1.464 (1.089-1.969)	0.012

^aCohorts were calculated using the Cox proportional hazards regression model. Bold indicates statistically significant values. ^bMultivariate analysis used the covariates associated with survival in the univariate models (). The Wald statistic was applied to test whether the covariates were independent variables (). Bold indicates statistically significant values.