Research Article
Mutations in the BRAF, NRAS, and C-KIT Genes of Patients Diagnosed with Melanoma in Colombia Population
Table 1
Mutation analysis by gene and patient clinicopathologic characteristics.
| | Mutation | WT | Mutation | WT | Mutation | WT |
| | Mean age | 61.27 (27-81) | 63.73 (41-86) | 61.38 (30-86) | 62.63 (27-85) | 56.5 (44-74) | 62.2 (27-86) | | Sex | | Man | 13 | 7 | 7 | 13 | 0 | 20 | | Woman | 22 | 12 | 14 | 20 | 4 | 30 | | Anatomical site | | Trunk | 6 | 2 | 5 | 3 | 1 | 7 | | Extremities | 5 | 2 | 1 | 3 | 1 | 3 | | Feet and hands | 8 | 5 | 6 | 10 | 0 | 16 | | Head and neck | 16 | 10 | 9 | 17 | 2 | 24 | | Melanoma subtype | | Lentigo maligna melanoma | 19 | 9 | 8 | 20 | 2 | 26 | | Superficial spreading melanoma | 3 | 0 | 1 | 2 | 1 | 2 | | Acral lentiginous melanoma | 6 | 7 | 3 | 10 | 1 | 12 | | Nodular melanoma | 5 | 5 | 9 | 1 | 0 | 10 | | Phototype | | I | 6 | 2 | 1 | 7 | 2 | 6 | | II | 25 | 16 | 17 | 24 | 2 | 39 | | III | 3 | 1 | 3 | 1 | 0 | 4 | | IV | 1 | 0 | 0 | 1 | 0 | 1 | | Clark | | II | 6 | 1 | 4 | 3 | 2 | 5 | | III | 2 | 1 | 1 | 2 | 0 | 3 | | IV | 8 | 2 | 4 | 6 | 0 | 10 | | V | 1 | 1 | 2 | 0 | 0 | 2 | | Breslow | | 0.1 mm to 1 mm | 5 | 0 | 1 | 4 | 1 | 4 | | >1 mm to 2 mm | 4 | 1 | 3 | 2 | 1 | 4 | | >2 mm to 4 mm | 3 | 2 | 2 | 3 | 0 | 5 | | >4 mm | 7 | 3 | 5 | 5 | 0 | 10 | | Ulceration | | Present | 8 | 2 | 6 | 4 | 0 | 10 | | Absent | 11 | 4 | 6 | 9 | 2 | 13 | | Nevus | | <50 | 31 | 17 | 18 | 30 | 2 | 46 | | 50-100 | 2 | 2 | 3 | 1 | 1 | 3 | | >100 | 2 | 0 | 0 | 2 | 1 | 1 |
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