A Functional Polymorphism in the Promoter Region of Interleukin-12B Increases the Risk of Colorectal Cancer

Table 2

Association between the two polymorphisms and the risk of CRC.

Group	Controls (%)	Cases (%)		OR (95%CI)
	N = 342	N = 329
rs17860508 genotype
TTAGAG/TTAGAG	103 (30.1)	71 (21.6)		Reference
TTAGAG/GC	166 (48.5)	167 (50.8)	0.045	1.46 (1.01–2.12)
GC/GC	73 (21.3)	91 (27.6)	0.007	1.81 (1.18–2.78)
Allele
TTAGAG	372 (54.4)	309 (47.0)		Reference
GC	312 (45.6)	349 (53.0)	0.007	1.35 (1.09–1.67)
rs3212227 genotype
AA	108 (31.6)	96 (29.2)		Reference
AC	173 (50.6)	160 (48.6)	0.824	1.04 (0.73–1.48)
CC	61 (17.8)	73 (22.2)	0.182	1.35 (0.87–2.09)
Allele
A	389 (56.9)	352 (53.5)		Reference
C	295 (43.1)	306 (46.5)	0.214	1.15 (0.92–1.42)

Abbreviations: CRC, colorectal cancer; OR, odds ratio; CI, confidence interval.