Bone Metastases Pattern in Newly Diagnosed Metastatic Nasopharyngeal Carcinoma: A Real-World Analysis in the SEER Database
Table 1
Univariate and multivariable logistic regression for analyzing the demographic and related clinical characteristics for developing bone metastases in patients diagnosed with initial NPC (diagnosed 2010–2016).
Subject characteristics
No. of NPC patients
Univariable
Multivariable
Without bone met (, %)
With bone met (, %)
OR (95% CI)
OR (95% CI)
Age
0-24
142 (92.8)
11 (7.2)
1 (reference)
1.0
1 (reference)
1.0
25-49
757 (90.8)
77 (9.2)
1.031 (0.535-1.988)
0.972
1.295 (0.528-2.881)
0.527
50-74
2066 (94.1)
129 (5.0)
0.800 (0.423-1.516)
0.494
0.978 (0.447-2.140)
0.956
75+
372 (95.4)
18 (4.6)
0.620 (0.286-1.346)
0.227
0.813 (0.314-2.103)
0.667
Gender
Female
1063 (95.9)
46 (4.1)
1 (reference)
1.0
1 (reference)
1.0
Male
2474 (92.9)
189 (7.1)
1.765 (1.269-2.456)
0.001
1.676 (1.134-2.478)
0.010
Race
White
1703 (94.7)
96 (5.3)
1 (reference)
1.0
1 (reference)
1.0
Black
425 (93.0)
32 (7.0)
1.336 (0.883-2.021)
0.171
0.893 (0.537-1.483)
0.662
Others
1409 (92.9)
107 (7.1)
1.347 (1.014-1.790)
0.040
1.003 (0.711-1.415)
0.985
Marital status
Married
1996 (94.1)
125 (5.9)
1 (reference)
1.0
1 (reference)
1.0
Single
1321 (93.2)
96 (6.8)
1.160 (0.882-1.528)
0.298
0.946 (0.664-1.348)
0.759
Unknown
220 (94.0)
14 (6.0)
NA
NA
NA
NA
Insurance status
Insured
2249 (94.7)
125 (5.3)
1 (reference)
1.0
1 (reference)
1.0
Uninsured
1142 (92.4)
94 (7.6)
1.481 (1.123-1.953)
0.005
1.256 (0.903-1.746)
0.176
Unknown
146 (90.1)
16 (9.9)
NA
NA
NA
NA
T stage
T0
19 (86.4)
3 (13.6)
1 (reference)
1.0
1 (reference)
1.0
T1
1001 (96.3)
38 (3.7)
0.240 (0.068-0.848)
0.027
0.455 (0.096-2.149)
0.320
T2
525 (96.0)
22 (4.0)
0.265 (0.073-0.964)
0.044
0.457 (0.094-2.229)
0.333
T3
594 (94.3)
36 (5.7)
0.384 (0.109-1.358)
0.137
0.632 (0.133-3.018)
0.566
T4
715 (91.1)
70 (8.9)
0.620 (0.179-2.147)
0.451
0.917 (0.197-4.266)
0.911
Unknown
683 (91.2)
66 (8.8)
NA
NA
NA
NA
N stage
N0
797 (96.6)
28 (3.4)
1 (reference)
1.0
1 (reference)
1.0
N1
970 (95.1)
50 (4.9)
1.467 (0.915-2.352)
0.111
1.086 (0.630-1.873)
0.767
N2
766 (93.1)
57 (6.9)
2.118 (1.333-3.366)
0.001
1.844 (1.085-3.136)
0.024
N3
405 (89.0)
50 (11.0)
3.514 (2.179-5.667)
<0.05
2.052 (1.166-3.611)
0.013
Unknown
599 (92.3)
50 (7.7)
NA
NA
NA
NA
Liver Met
None
3488 (95.8)
152 (4.2)
1 (reference)
1.0
1 (reference)
1.0
Yes
48 (37.8)
79 (62.2)
37.768 (25.457-55.991)
<0.05
23.742 (15.261-36.938)
<0.05
Unknown
1 (20.0)
4 (80.0)
NA
NA
NA
NA
Brain Met
None
3519 (94.4)
209 (5.6)
1 (reference)
1.0
1 (reference)
1.0
Yes
18 (47.4)
20 (52.6)
18.708 (9.748-35.904)
<0.05
10.372 (4.505-23.676)
<0.05
Unknown
0 (0.0)
6 (100.0)
NA
NA
NA
NA
Lung Met
None
3431 (95.3)
171 (4.7)
1 (reference)
1.0
1 (reference)
1.0
Yes
99 (62.3)
59 (37.3)
11.958 (8.367-17.089)
<0.05
6.027 (3.835-9.473)
<0.05
Unknown
7 (58.3)
5 (41.7)
NA
NA
NA
NA
Sequence number
One primary only
2946 (93.3)
212 (6.7)
1 (reference)
1.0
1 (reference)
1.0
Others
591 (96.3)
23 (3.7)
1.849 (1.192-2.869)
0.006
1.298 (0.777-2.167)
0.319
All factors with unknown data were removed from the Cox and Kaplan–Meier model. NPC: nasopharyngeal carcinoma; IQR: interquartile range; Met: metastases; NA: not available.
