Identification of lncRNA and mRNA Biomarkers in Osteoarthritic Degenerative Meniscus by Weighted Gene Coexpression Network and Competing Endogenous RNA Network Analysis

Figure 6

ceRNA network and hub RNA efficacy evaluation. (a) In network, gray edges indicate lncRNA-miRNA-mRNA interactions. Squares represent lncRNAs, triangles represent miRNAs, and circles represent protein-coding mRNAs. (b) The expression of five hub RNAs in GSE98918, red represents KOA samples and blue represents controls. (c–g) ROC curve of five hub RNAs for patients with KOA. AUC: the area under the ROC curve. (h) Validation of hub mRNAs in GSE113825. IGFBP4: insulin-like growth factor binding protein 4; KLF2: Kruppel-like factor 2; OA: osteoarthritis; indicates .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)