Identification of Four Pathological Stage-Relevant Genes in Association with Progression and Prognosis in Clear Cell Renal Cell Carcinoma by Integrated Bioinformatics Analysis

Figure 4

Weighted gene coexpression analysis for TCGA and screening for intramodular hub genes of key modules. (a) The clustering dendrogram based on the dissimilarity (1-TOM) using the dynamic tree cut method. (b) Module-trait relationship heat map based on the Pearson correlation coefficient between module eigengenes and clinical parameters (gender, age, grade, and stage). (c) Barplot for average gene significance across modules associated with the pathological stage for ccRCC. (d) Scatter plot of module eigengenes in the dark-gray module from GSE73731. (e) Scatter plot of module eigengenes in the cyan module from TCGA. Dots in the upper-right corner in both plots represent hub genes in the module.

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