Preparation, Optimization, and Evaluation of Epichlorohydrin Cross-Linked Enset (Ensete ventricosum (Welw.) Cheeseman) Starch as Drug Release Sustaining Excipient in Microsphere Formulation

Table 11

Summary of ANOVA results for response surface quadratic model for DC and response surface factor interaction model for drug release rate of the microsphere formulations.

Responses	Source	Sum of	df	Mean	value	value	Remark
	Squares		Square
DC (%)	Model	5732.28	5	1146.46	33.06	<0.0001	Significant
	A-ECH	3101.30	1	3101.30	89.42	<0.0001	Significant
	B-time	1891.45	1	1891.45	54.54	0.0002	Significant
	AB	238.70	1	238.70	6.88	0.0342	Significant
	A^2	384.50	1	384.50	11.09	0.0126	Significant
	B^2	424.67	1	424.67	12.24	0.0100	Significant
	Residual	242.77	7	34.68
	Lack of fit	147.07	3	49.02	2.05	0.2497	Insignificant
	Pure error	95.70	4	23.92
	Cor Total	5975.05	12
Release rate(h^1/2)	Model	77.04	3	25.68	42.58	<0.0001	Significant
	A-ECH	52.15	1	52.15	86.48	<0.0001	Significant
	B-time	16.77	1	16.77	27.80	0.0005	Significant
	AB	8.12	1	8.12	13.47	0.0672	Insignificant
	Residual	5.43	9	0.60
	Lack of fit	3.60	5	0.72	1.60	0.3355	Insignificant
	Pure error	1.81	4	0.45
	Cor Total	82.47	12

df = degree of freedom.