Preparation, Optimization, and Evaluation of Epichlorohydrin Cross-Linked Enset (Ensete ventricosum (Welw.) Cheeseman) Starch as Drug Release Sustaining Excipient in Microsphere Formulation

Table 13

Constraints of factors and responses for the optimization of release rate and DC of theophylline loaded CLS.

Constraints
Factor constraints
Factor	Low		High
Conc. ECH (%)	3		16
Length of cross-linking time (h)	1		10
Response constraints
Response	Goal	Lower limit	Upper limit	Importance
Release rate (h^1/2)		26	30	+++++
Degree of cross-linking (%)	Maximize	60	90	++++