Preparation, Optimization, and Evaluation of Epichlorohydrin Cross-Linked Enset (Ensete ventricosum (Welw.) Cheeseman) Starch as Drug Release Sustaining Excipient in Microsphere Formulation

Table 5

Summary of the effects of different parameters on response variable (release rate and DC).

Formulations	(ECH) (%, )	Parameters and their levels		Response variable
		Cross-linking time (h)	Reaction temperature (°C)	DC (%)	Release rate (h^1/2)
F-1	3	1	54		31.6
F-2	3	10	54		28.4
F-3	3	10	25		28.9
F-4	16	10	25		26.8
F-5	16	1	54		29.5
F-6	16	1	25		30.3
F-7	16	10	54		27.9
F-8	3	1	25		32.4