Preparation, Optimization, and Evaluation of Epichlorohydrin Cross-Linked Enset (Ensete ventricosum (Welw.) Cheeseman) Starch as Drug Release Sustaining Excipient in Microsphere Formulation

Table 7

Rate constants and correlation coefficients of the drug release kinetic models for all the thirteen microsphere formulations.

Formulations	Release kinetic models
	Zero-order		First-order		Higuchi square root		Hixson-Crowell
	Slope		Slope		Slope		Slope
F-1	9.859	0.990	-0.069	0.771	29.71	0.994	-0.191	0.815
F-2a	6.652	0.887	-0.094	0.887	29.80	0.979	-0.181	0.905
F-3	6.400	0.916	-0.059	0.707	27.60	0.994	-0.188	0.830
F-4	4.628	0.854	-0.034	0.728	22.00	0.986	-0.158	0.901
F-5b	—	—	—	—	—	—	—	—
F-6c	6.159	0.815	-0.057	0.606	26.01	0.968	-0.168	0.842
F-7d	6.307	0.945	-0.067	0.783	31.71	0.995	-0.147	0.829
F-8e	4.207	0.987	-0.089	0.855	24.03	0.975	-0.179	0.913
F-9	6.931	0.844	-0.083	0.586	26.50	0.978	-0.126	0.928
F-10	5.069	0.782	-0.061	0.564	28.30	0.952	-0.184	0.860
F-11	4.111	0.897	-0.058	0.714	27.23	0.994	-0.118	0.931
F-12	5.965	0.881	-0.064	0.653	27.40	0.990	-0.152	0.893
F-13	6.405	0.985	-0.130	0.905	26.92	0.974	-0.128	0.851

“-”: denotes for not analyzed.