Heat Shock Protein 90 Family Isoforms as Prognostic Biomarkers and Their Correlations with Immune Infiltration in Breast Cancer
Table 2
Correlations between HSP90s gene expression and biomarker expression of subsets of TIICs in BRAC from the TIMER.
Types of TIICs
Gene markers
HSP90AA1
HSP90AB1
HSP90B1
TRAP1
B cell
CD19
-0.02
4.90-01
-0.01
7.71-01
0.01
8.13-01
0.04
2.19-01
CD79A
-0.04
1.81-01
0.00
9.59-01
0.00
9.37-01
0.02
5.76-01
T cell (general)
CD3D
-0.08
1.53-02
-0.03
3.43-01
0.02
4.88-01
-0.01
6.66-01
CD2
0.02
5.01-01
0.04
1.90-01
0.08
1.62-02
-0.02
5.87-01
Th1
TBX21
-0.05
1.42-01
0.02
5.04-01
0.06
4.77-02
0.02
6.08-01
STAT4
0.06
7.49-02
0.01
7.21-01
0.08
7.90-03
-0.10
2.04-03
STAT1
0.33
1.08-26
0.29
1.25-20
0.34
3.99-28
0.03
3.26-01
TNF
0.03
3.79-01
0.08
9.84-03
0.13
4.54-05
0.16
6.65-07
IFNG
0.08
1.17-02
0.12
2.14-04
0.20
2.28-10
0.01
7.89-01
Th2
GATA3
0.02
5.29-01
-0.04
2.66-01
-0.20
3.90-10
0.02
6.23-01
STAT6
0.01
7.19-01
-0.05
1.31-01
-0.12
2.52-04
0.07
2.13-02
IL13
-0.02
5.17-01
0.02
5.00-01
0.03
2.99-01
-0.02
5.44-01
STAT5A
-0.16
2.45-07
-0.12
2.16-04
-0.08
9.34-03
0.10
1.66-03
Tfh
BCL6
0.00
8.88-01
-0.11
7.79-04
-0.03
3.59-01
-0.06
4.91-02
IL21
0.14
9.53-06
0.15
2.34-06
0.16
4.56-07
-0.01
7.24-01
Th17
STAT3
0.22
1.13-12
0.09
3.25-03
0.17
1.03-07
0.07
1.82-02
IL17A
0.05
1.19-01
0.09
4.78-03
0.12
1.04-04
0.01
7.77-01
Treg
FOXP3
0.14
6.97-06
0.15
1.76-06
0.13
2.50-05
0.04
2.43-01
CCR8
0.32
4.12-25
0.28
3.19-19
0.23
1.86-13
0.05
1.10-01
TGFB1
-0.13
4.31-05
-0.16
7.90-07
-0.12
9.55-05
-0.06
6.26-02
CD8+ T
CD8A
0.00
9.85-01
0.04
2.59-01
0.05
1.25-01
-0.02
6.23-01
CD8B
-0.03
3.52E-01
0.00
9.95-01
0.04
1.98-01
0.02
4.75-01
T cell exhaustion
PDCD1
-0.08
1.04-02
0.00
9.63-01
0.02
4.87-01
0.03
3.32-01
CTLA4
0.07
2.95-02
0.11
8.57-04
0.17
7.80-08
0.05
1.56-01
LAG3
0.01
8.24-01
0.10
2.02-03
0.12
8.62-05
0.05
9.93-02
TIM3
0.15
1.35-06
0.08
8.06-03
0.21
2.01-11
-0.05
9.84-02
GZMB
0.03
2.80-01
0.09
2.87-03
0.17
8.65-08
0.02
4.44-01
NK cell
KIR2DL1
0.03
2.77-01
0.08
1.20-02
0.13
1.96-05
-0.01
7.62-01
KIR3DL3
0.00
9.47-01
0.04
2.64-01
0.11
3.48-04
-0.02
5.83-01
KIR3DL1
0.01
6.77-01
0.04
2.14-01
0.10
1.47-03
-0.01
7.28-01
KIR3DL2
0.02
4.77-01
0.06
8.03-02
0.07
2.20-02
-0.01
7.71-01
KIR3DL3
0.00
9.47-01
0.04
2.64-01
0.11
3.48-04
-0.02
5.83-01
KIR2DS4
0.03
3.87-01
0.07
2.49-02
0.09
4.81-03
-0.03
3.58-01
Neutrophils
CD11b
0.04
2.60-01
-0.03
3.98-01
0.07
3.23-02
0.06
5.79-02
CCR7
-0.01
6.45-01
0.03
3.75-01
-0.03
3.37-01
-0.01
7.77-01
CD66b
0.00
9.75-01
-0.04
1.83-01
0.00
8.80-01
-0.03
3.61-01
M1 macrophages
NOS2
0.03
3.39-01
0.06
4.50-02
0.06
6.34-02
-0.07
2.10-02
PTGS2
0.02
4.91-01
-0.01
7.49-01
0.10
1.17-03
-0.12
1.40-04
IRF5
0.01
7.84-01
0.11
2.92-04
0.16
6.25-07
0.02
5.31-01
M2 macrophages
CD163
0.21
3.01-11
0.23
4.52-13
0.29
3.17-21
0.02
6.25-01
VSIG4
0.09
6.51-03
0.08
1.25-02
0.16
8.74-07
-0.05
1.02-01
MS4A4A
0.16
2.37-07
0.13
5.38-05
0.19
7.28-10
-0.09
5.86-03
TAM
CCL2
0.06
5.66-02
0.04
1.70-01
0.14
5.57-06
-0.08
1.20-02
CD68
0.16
3.26-07
0.11
4.71-04
0.21
1.45-11
-0.01
8.13-01
IL10
0.19
1.42-09
0.15
2.04-06
0.22
1.38-12
-0.01
6.68-01
Monocyte
CD86
0.14
6.49-06
0.11
5.58-04
0.25
3.58-15
-0.05
1.28-01
CD115
-0.04
2.63-01
-0.03
2.88-01
0.11
2.88-04
-0.07
2.22-02
DC
HLA-DPB1
-0.19
1.34-09
-0.17
8.39-08
-0.08
7.37-03
-0.03
3.46-01
HLA-DRA
0.04
2.25-01
-0.02
6.17-01
0.10
1.45-03
-0.05
1.09-01
HLA-DQB1
-0.11
7.12-04
-0.07
1.90-02
-0.01
8.42-01
0.04
2.44-01
HLA-DPA1
0.00
8.91-01
-0.06
5.51-02
0.08
1.70-02
-0.08
1.53-02
CD1C
-0.14
1.05-05
-0.15
3.10-06
-0.15
1.49-06
-0.08
7.67-03
NRP1
0.16
5.78-07
0.00
8.97-01
0.09
5.97-03
-0.22
4.26-12
CD11c
0.03
3.55-01
0.02
6.27-01
0.07
3.68-02
0.00
9.28-01
Note: the correlation analysis was adjusted for the tumor purity. values with statistical significance are shown in bold. Abbreviations: TAM: tumor-associated macrophage; Th: helper T cell; Tfh: follicular helper T cell; Treg: regulatory T cell; NK: natural killer cell; : value of Spearman’s correlation.
