Prognostic Values of Transforming Growth Factor-Beta Subtypes in Ovarian Cancer
Table 2
Correlation of TGF-β subtypes with OS and PFS in ovarian cancer patients with different pathological grades of disease.
TGF-β subtypes
Pathological grade
Cases
OS
value
Cases
PFS
value
HR (95% CI)
HR (95% CI)
TGF-β1
I
56
0.61 (0.23-1.63)
0.32
37
0.12 (0.02-0.91)
0.0014
II
324
1.41 (0.99-2.01)
0.057
256
0.85 (0.63-1.14)
0.27
III
1015
1.10 (0.92-1.31)
0.3
837
0.83 (0.69-1.00)
0.056
TGF-β2
I
56
0.54 (0.21-1.41)
0.2
37
0.48 (0.12-1.58)
0.22
II
324
1.40 (1.01-1.95)
0.045
256
1.33 (0.98-1.8)
0.069
III
1015
1.30 (1.1-1.54)
0.0017
837
1.42 (1.20-1.68)
0.001
TGF-β3
I
56
2.31 (0.89-6.02)
0.076
37
1.90 (0.64-5.66)
0.24
II
324
1.50 (1.09-2.07)
0.0012
256
1.68 (1.25-2.26)
0.0005
III
1015
1.18 (1.00-1.39)
0.053
837
1.32 (1.12-1.57)
0.001
TGF-β4
I
56
0.66 (0.24-1.80)
0.42
37
7.86 (1.02-60.55)
0.019
II
324
0.80 (0.59-.08)
0.14
256
0.80 (0.59-1.09)
0.15
III
1015
1.16 (0.98-1.36)
0.0880
837
1.21 (1.02-1.43)
0.025
Notes: pathological grade I (well differentiated), pathological grade II (moderately differentiated), and pathological grade II (poorly differentiated). .
